经鼻蝶垂体瘤切除术后脑脊液鼻漏的影响因素分析
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王秋萍,Email:qpwang1016@vip.sina.com

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呼吸疾病国家重点实验室开放课题(2007DA780154F090)


Stratified analysis of lower airway inflammation predisposing factors among subjects with chronic rhinitis
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    摘要:

    目的通过对慢性鼻炎患者多因素分层研究,分析其下气道炎症特征和程度以及鼻、下气道、炎症相关危险因素的分布,探讨慢性鼻炎患者下气道炎症的危险因素。方法随机选取2007年1月~2012年12月就诊的639例慢性鼻炎患者经变应原皮肤点刺试验(SPT),其中377例为SPT阳性患者,262例为SPT阴性患者。采用统一的调查表采集患者一般资料;检测鼻分泌物涂片、鼻灌洗嗜酸细胞(EOS)计数、鼻激发,诱导痰EOS计数及血EOS等炎症相关生物指标。采用分层和多因素Logistic回归模型对上述指标进行统计学分析。结果慢性鼻炎患者下气道炎症阳性率为49.30%(315/639)。SPT阳性患者下气道炎症阳性率为60.48%(228/377),SPT阴性患者下气道炎症阳性率33.20%(87/262),两者之间比较差异具有统计学意义(P<0.01);鼻灌洗EOS计数升高患者下气道炎症阳性率为70.81%(211/298),鼻灌洗EOS计数正常患者下气道炎症阳性率为30.50%(104/341),两者之间比较差异具有统计学意义(P<0.01)。而患者下气道炎症阳性率与性别、是否吸烟、血EOS及鼻激发结果无明显相关性。结论SPT阳性和鼻灌洗EOS计数升高是慢性鼻炎患者增加下气道炎症的危险因素。

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    ObjectiveTo investigate the characteristics and extent of lower airway inflammation in patients with chronic rhinitis, and to explore the risk factors in lower airway inflammation in rhinitis patients.MethodsFrom Jan 2007 to Dec 2012, 639 chronic rhinitis patients were collected, including 377 positive SPT and 262 negative SPT according to results of SPT. General information of all patients was collected with uniform questionnaire. Eosinophil (EOS) counts of blood, nasal lavage fluid and induced sputum, nasal secretions smear, nasal or bronchial provocation were performed. Stratified and multivariate logistic regression models were used for statistical analysis.ResultsThe total positive rate of lower airway inflammation in patients with rhinitis was 49.30%, while those in positive SPT and negative SPT were 60.48% and 33.20% respectively with a significant difference (P<0.01). The positive rates of lower airway inflammation in patients with increased and normal nasal lavage EOS counts were 70.81% and 30.50%, and the difference was statistically significant (P<0.01). While, the positive rates of lower airway inflammation in patients were not significant correlated with the sex, smoking, blood EOS and nasal provocation.ConclusionThe predisposing factors in lower airway inflammation in rhinitis patients are positive SPT and increased EOS count in nasal lavage fluid.

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吴明海,王秋萍,张恺 ,吴昆旻,张勇,王志颐,季俊峰,程友,钟南山.经鼻蝶垂体瘤切除术后脑脊液鼻漏的影响因素分析[J].中国耳鼻咽喉颅底外科杂志,2014,20(2):127-130

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  • 在线发布日期: 2014-04-30
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