Abstract:Objective To investigate the effect of MEBT/MEBO on the healing of mucosa wounds after endoscopic sinus surgery through detecting expression of metrix metalloproteinase9 (MMP9) and eosinophil (EOS). Methods 45 cases with chronic sinusitis receiving endoscopic sinuous surgery were randomly divided into two groups, MEBT and vaseline gauze were applied to the surgical mucosa wounds in the experimental group (n=24) and the control group (n=21) respectively. The expression of MMP9 and EOS in both groups was detected with immunohistochemical method and HE staining respectively 2 weeks after surgery. Results The HE staining showed that the EOS number of the control group was higher than that of the experimental group while the immunohistochemical detection showed that the number and intensity of MMP9 positively stained cells in the experimental group were higher than those in the control group. The differences between the two groups were statistically significant (P<0.05). Conclusion Application of MEBT to the surgical wounds after endoscopic sinus surgery can promote the epithelization process in the mucosa wounds through a possible mechanism of inhibiting the expression of MMP9 and reducing the number of EOS in the mucosa.