ObjectiveTo investigate the feasibility and curative effect of resection of infratemporal fossa benign tumors via endoscopic preauricular infratemporal fossa approach．MethodsThe surgical records and medical charts of 1 male and 4 females (age ranged from 41 to 59 years old with a mean age of 51) diagnosed with infratemporal fossa tumors and operated via endoscopic preauricular infratemporal fossa approach in our hospital between Feb 2017 and Sept 2019 were reviewed. As for the symptoms, 4 cases complained of chewing discomfort, 3 cases complained of headache, 2 cases complained of decreased hearing. Physical examinations detected bulging temporal zygomatic area of the affected side in 3 patients．ResultsComplete removal of the tumor was achieved in all the 5 cases with the operative time from 1.5h to 3.0h. Postoperatively, all patients felt temporary weak mastication, slightly less closing force and less swelling on the affected side, which returned to normal about 2 months later. Postoperative numbness in the lower jaw of the affected side was observed in one case through 12 months after the operation．All incisions healed at grade A. There was no evidence of permanent complications and local recurrence through a median followup time of 18 months (ranged from 6 to 26 months). Postoperative pathology revealed giant cell reparative granulomas in 2 cases, giant cell tumor of bone in 2, and phosphaturic mesenchymal tumor in one.ConclusionWith advantages of good safety and effectiveness as well as minimal invasion, the endoscopic preauricular infratemporal fossa approach is worth promoting in complete removal of some select group of benign tumors involving the superior of infratemporal fossa near temporomandibular joint.