Abstract:Abstract: Objective To analyze the changes in the response amplitude of distortion product otoacoustic emissions (DPOAE) before and after drug treatment in three groups of high-profile tinnitus patients with acute tinnitus, subacute tinnitus, and chronic tinnitus, and the amplitude of DPOAE response in three groups of high-profile tinnitus patients with different onset duration before and after drug treatment Analysis of the difference results, to understand the influence of drug treatment on the DPOAE response amplitude of patients with high-profile tinnitus, and to analyze the relationship between drug efficacy and the duration of the disease. Methods According to the duration of onset, the patients with normal hearing and high-profile tinnitus were divided into three groups: acute tinnitus group (disease duration ≤ 3 months), 25 cases (27 ears); subacute tinnitus group (3 ﹤ disease course ≤ 12 months), 23 cases ( 26 ears), chronic tinnitus group (disease duration> 12 months), 20 cases (24 ears), the three groups of patients were tested for the DPOAE response amplitude, after two weeks of drug treatment, the DPOAE response amplitude of the three groups was measured again, To preliminarily evaluate the influence of drug treatment on the magnitude of DPOAE response in tinnitus patients and the relationship between drug efficacy and the duration of the disease. Results After two weeks of drug treatment, the three groups of patients had no statistically significant differences in the changes in DPOAE response amplitude between 0.500~1.000 KHz and the difference in DPOAE response amplitude. However, at the frequency of 2.000~8.000KHz, except for the change of the DPOAE response amplitude of the third group of patients before and after the 6,000 and 8,000 kHz treatments, the DPOAE response amplitude of each group of patients after drug treatment The changes in DPOAE were statistically significant (P<0.05), and the difference in DPOAE response amplitudes before and after treatment in the three groups was also statistically significant (P<0.05). The changes in the DPOAE elicitation rate of the three groups of patients before and after treatment were not statistically significant at the frequency of 0.500-1.500KHz; there was statistical significance at the frequency of 2.000~8.000KHz, but the third group of patients was at the frequency of 6.000 and 8.000 kHz except points.After drug treatment, the effective rates of the three groups of patients were 100% in the first group, 65.38% in the second group, and 29.17% in the third group. The effective rate of treatment was compared among the three groups, and the difference was statistically significant (χ2 = 19.38, P <0.01). The changes in the DPOAE elicitation rate of the three groups of patients before and after treatment were statistically significant at the frequency of 2.000~8.000KHz, using the χ2 test, P<0.05, but the third group of patients had no elicitation rate before and after the treatment of 6,000 and 8,000 kHz.Conclusion It is an effective treatment method to give high-profile tinnitus patients to improve the inner ear microcirculation and other drugs. The shorter the onset time, the greater the increase in the DPOAE response amplitude after treatment, and the higher the effective rate after treatment, indicating that the shorter the course of the disease, the better the effect. It is better to allow early detection and early intervention to increase the cure rate and improve the quality of life of patients.