Abstract:OOBJECTIVES: Through 3D reconstruction of skull base tumor and surrounding tissue structure, anatomical parameters of skull base tumor and surrounding structure were obtained, and individualized 3D model was constructed and printed to study the role and application value of 3D printing technology in surgical treatment of skull base tumor. METHODS: Clinical data of patients with complex cranial base tumors (including meningioma, pituitary tumor, olfactory neuroblastoma, craniopharyngioma, schwannoma and chordoma) admitted to Tianjin Huanhu Hospital from May 2019 to January 2021 were collected. According to the original data of patients' preoperative imaging (computed tomography CT, magnetic resonance imaging MRI, computed tomography angiography Angiography CTA and 3D reconstruction), "MINICS" software was used to read the original imaging images of patients, and 3D printing software and 3D reconstruction technology were used to personalized design the surgical plan of skull base occupation. RESULTS: Three-dimensional reconstruction and printing of individual models of skull base tumors and surrounding structures in the above 15 patients. The distribution and route of important blood vessels around the tumor were analyzed according to the 3D reconstruction model to protect and prevent injury during operation.15 patients were successfully completed surgery, of which 14 cases were obtained, subtotal resection in 1 case most resection (to postoperative radiotherapy), 14 patients recovered well after operation and no tumor recurrence and postoperative complications, most resection in 1 case (squamous cell carcinoma (SCC) of patients with postoperative relapse, to surgery plus radiotherapy combined with comprehensive improvement after treatment. CONCLUSIONS: Personalized 3D model of skull base tumor printed by 3D technology can be used to design and plan the resection of skull base tumor and postoperative repair and reconstruction, which is of great significance for guiding clinical complete resection of tumor tissue, protection of adjacent nerves and blood vessels, and postoperative repair of defects.