1.贵州医科大学;2.贵州省人民医院
贵州省人民医院院级课题青年基金GZSYQN[2022]04
Guizhou Medical University
- 摘要 | |
- 访问统计 |
- 参考文献 | |
- 引证文献 |
头颈部鳞状细胞癌（HNSCC）是全球第六大常见癌症，五年生存率仍低于50%。近年来，细胞焦亡作为一种新发现的细胞程序性死亡方式引起了广泛关注。这一过程由炎性半胱氨酸天冬酶（Caspase）激活，并通过依赖gasdermin蛋白家族来形成质膜孔。研究表明，细胞焦亡在肿瘤进展和治疗抵抗中起着重要作用。活化的炎性小体，作为核苷酸结合寡聚化结构域样受体（NLR）的一个成员，能激活Caspase-1，从而诱导炎症效应和细胞焦亡，进一步影响肿瘤疾病的进展。然而，关于细胞焦亡和HNSCC之间关系的研究仍然有限。本文综述了现有的研究成果，并强调了更多针对细胞焦亡在HNSCC中作用的研究的重要性。
Head and Neck Squamous Cell Carcinoma (HNSCC) ranks as the sixth most common cancer globally, with a five-year survival rate still less than 50%. Recently, pyroptosis, a newly identified form of programmed cell death, has gained significant attention. This process is activated by inflammatory Caspases and relies on the gasdermin protein family to form pores in the cell membrane. Studies indicate that pyroptosis plays a vital role in both tumor progression and therapy resistance. Activated inflammasomes, as members of the Nucleotide-binding Oligomerization Domain-like Receptor (NLR) family, trigger Caspase-1, thereby inducing inflammatory effects and pyroptosis, further influencing the course of the tumor disease. However, research relating pyroptosis to HNSCC remains limited. This article reviews current findings and underscores the importance of further studies focusing on the role of pyroptosis in HNSCC.
