Objective: Given that periostin(POSTN)mediates bronchial airway remodeling in asthmatic patients, we aim to find new ideas for clinical examination and targeted drugs by means of the analysis of nasal secretion of allergic rhinitis(AR).Methods: Nasal secretion was collected from patients with AR and normal controls, and IL-4, Il-13 and periostin (POSTN) were detected by ELISA, respectively.Meanwhile, TNSS was used to evaluate the patients in the experimental group and the indexes were obtained. Correlation analysis was carried out subsquently.Results: The levels of IL-4, IL-13 and POSTN in the nasal secretion of patients were significantly higher than normal (P < 0.05), and there was a significant correlation between IL-4, IL-13 and POSTN in the test group (R > 0.5), as well as between POSTN and the degree of morbidity of patients (R > 0.5). Conclusion: Periostin plays an important role in the pathogenesis of allergic rhinitis. Interleukin-4 and interleukin-13 can induce the synthesis of periostin in patients with allergic rhinitis. It is possible to administer drugs through this target, which could provide ideas for the treatment of allergic rhinitis. Measuring periostin levels in nasal secretions can help diagnose and analyze the severity of symptoms in patients with allergic rhinitis.