Objective To summarize the treatment of chylorrhea caused by cervical lymph node dissection. Methods The clinical data of 6 cases of chylorrhea diagnosed and treated by the Department of Otolaryngology, Head and Neck Surgery, Tangdu Hospital, Air Force Military Medical University from July 2021 to May 2023 were retrospectively analyzed. There were 1 case of chylorrhea after right central lymph node dissection and 5 cases of chylorrhea after bilateral neck lymph node dissection. Among the 6 patients, there was 1 intraoperative and postoperative chylorrhea, 1 intraoperative chylorrhea, and 4 postoperative chylorrhea. The treatment of chylous leakage during and after operation was analyzed comprehensively. Results All patients with chylorrhea were cured after corresponding treatment. Among the 6 patients, 1 case of chylorrhagia was treated with local ligation of the left jugular vein corner plus closure of the omohyoid muscle flap. The patient was cured again on the 2nd day after surgery after conservative treatment including fasting, intravenous nutrition, bed rest, continuous drainage, pressure bandaging and 50% hypertonic glucose solution injection. The other patient had a large amount of chylorrhea during the operation, and underwent local ligation of the left jugular vein corner and myoplasmic bioadhesive closure of the omohyoid muscle flap, but no chylorrhea occurred after the operation. In the other 4 patients, chylorrhea was not found during the operation, but appeared after the operation. 3 patients were cured after the conservative treatment described above, and the remaining 1 patient was cured after the conservative treatment failed, and thoracoscopic exploration plus thoracic catheter ligation was performed. Conclusion Chylorrhea is a serious complication caused by cervical lymph node dissection. If it occurs during the operation, local ligation of the left jugular vein corner and myoplasmic closure of the omohyoid muscle flap are feasible. If it occurs after surgery, most patients can be cured after active conservative treatment; If the conservative treatment is not effective, thoracoscopic exploration can be performed with thoracic catheter ligation.