成都市变应性鼻炎患者吸入性变应原类型及分布特征研究
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成都市第二人民医院

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四川省科技厅重点研发项目(N:2021YFS0036);


Study on the types and distribution characteristics of inhaled allergens in patients with allergic rhinitis in Chengdu
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    摘要:

    【】目的:对成都市变应性鼻炎(AR)患者吸入性变应原类型及分布特征进行分析,为本地AR的预治提供参考依据。方法:2019年1月-2022年12月成都市第二人民医院耳鼻喉门诊12486例资料齐全的接受变应原检测的AR患者作为研究对象,分析变应原类型及分布特征。结果:12486例AR患者中单一变应原过敏占43.31%;双重或多重变应原过敏占56.69%。单一变应原过敏与双重或多重变应原过敏者变应原前三位均为尘螨、豚草、猫皮屑。尘螨+++以上的患者占61.83%和77.52%。2-14岁组AR患者占比为38.49%,高于15-24岁组的21.39%、25-34岁组的18.46%、35-44岁组的8.87%、≥45岁组的12.79%;15-24岁组过敏患者占比高于35-44岁组、≥45岁组; 差异均有统计学意义(P<0.05)。2-14岁组过敏患者双重及以上过敏患者构成比例高于15-24岁组、25-34岁组%、35-44岁组、≥45岁组;15-24岁组过敏患者双重及以上过敏患者构成比例高于35-44岁组、≥45岁组;差异均有统计学意义(P<0.05)。2-14岁组、15-24岁组尘螨过敏率高于25-34岁组、35-44岁组和≥45岁组,差异均有统计学意义(P<0.05)。夏季、秋季过敏率分别为36.02%、33.04%,高于春季的12.54%和冬季的18.40%;且夏季尘螨过敏率为81.08%,高于春季、秋季、冬季;春季豚草过敏率高于夏季、秋季、冬季,差异有统计学意义(P<0.05)。2022年、2021年、2020年AR患者的构成比例高于2019年,差异有统计学意义(P<0.05)。2022年、2021年、2020年尘螨过敏比例高于2019年;2022年、2021年尘螨过敏比例高于2020年;2022年猫皮屑过敏比例高于2019年、2020年;差异有统计学意义(P<0.05)。结论:成都市近年来AR的发病率呈上升趋势,尘螨是最主要的吸入性变应原,夏秋季是过敏季节的高发季节,儿童较成年人更易过敏,且易发生多重过敏。

    Abstract:

    【】Objective: To analyze the types and distribution characteristics of inhaled allergens in patients with allergic rhinitis (AR) in Chengdu, and to provide reference for local AR pre-treatment. Methods: From January 2019 to December 2022, 12486 AR patients with complete data who received allergen detection in the otolaryngology outpatient department of Chengdu Second People"s Hospital were used as research objects to analyze the types and distribution characteristics of allergens. Results: Single allergen allergy accounted for 43.31% of 12486 AR patients. Double or multiple allergen allergy accounted for 56.69%. The top three allergens of single allergen allergy and double or multiple allergen allergy were dust mites, ragweed and cat dander. Dust mite +++ patients accounted for 61.83% and 77.52%. The proportion of AR patients in 2-14 years old group was 38.49%, which was higher than 21.39% in 15-24 years old group, 18.46% in 25-34 years old group, 8.87% in 35-44 years old group and 12.79% in ≥45 years old group. The proportion of allergic patients in 15-24 years old group was higher than 35-44 years old group and ≥45 years old group. The differences were statistically significant (P < 0.05). The proportion of patients with double or more allergies in 2-14 years old group was higher than that in 15-24 years old group, 25-34 years old group, 35-44 years old group and ≥45 years old group. The proportion of patients with double or more allergies in 15-24 years old group was higher than that in 35-44 years old group and ≥45 years old group. The differences were statistically significant (P < 0.05). The rates of dust mite allergy in 2-14 years old and 15-24 years old groups were higher than those in 25-34 years old, 35-44 years old and ≥45 years old, and the differences were statistically significant (P < 0.05). The allergic rates in summer and autumn were 36.02% and 33.04%, respectively, higher than 12.54% in spring and 18.40% in winter. The rate of dust mite allergy in summer was 81.08%, which was higher than that in spring, autumn and winter. The allergic rate of ragweed in spring was higher than that in summer, autumn and winter, and the difference was statistically significant (P < 0.05). The proportion of AR patients in 2022, 2021 and 2020 was higher than that in 2019, and the difference was statistically significant (P < 0.05). The proportion of dust mite allergy in 2022, 2021 and 2020 was higher than that in 2019; The proportion of dust mite allergy in 2022 and 2021 was higher than that in 2020; The proportion of cat dander allergy in 2022 was higher than that in 2019 and 2020. The difference was statistically significant (P < 0.05). Conclusion: The incidence of AR in Chengdu has been on the rise in recent years, dust mites are the most important inhalation allergens, summer and autumn are the high incidence season of allergy, children are more susceptible to allergies than adults, and they are prone to multiple allergies.

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  • 收稿日期:2024-02-26
  • 最后修改日期:2024-04-03
  • 录用日期:2024-04-07
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