突发性耳聋患者血清SIRT1和PGC-1α表达与血清炎性因子及听力预后的相关性研究
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1.牡丹江市第二人民医院;2.哈尔滨医科大学附属第二医院耳鼻咽喉头颈外科;3.牡丹江市第二人民医院耳鼻咽喉科

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Study on the correlation between the expression of serum SIRT1 and PGC-1α, serum inflammatory factors and hearing prognosis in patients with sudden deafness
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1.Department of Otolaryngology,Mudanjiang Second People'2.'3.s Hospital

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    摘要:

    目的 探讨血清沉默信息调节因子相关酶1(SIRT1)、过氧化物酶体增殖物激活受体γ辅助激活因子-1α(PGC-1α)与突发性耳聋患者血清炎症因子水平以及听力预后的相关性。方法 选取2020年5月-2022年5月牡丹江市第二人民医院收治的88例突发性耳聋患者作为研究组,根据患者听力恢复情况分为预后良好组和预后不良组,另收集82例到牡丹江市第二人民医院进行体检的健康体检者为对照组。采用酶联免疫吸附法检测患者血清SIRT1、PGC-1α以及炎症因子-肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(L-1β)、超敏C反应蛋白(hs-CRP)水平。Pearson法分析患者血清SIRT1、PGC-1α水平与炎症因子水平的相关性。Logistic回归分析听力预后的影响因素。结果 研究组有高血压史、糖尿病史比例高于对照组,SIRT1、PGC-1水平显著低于对照组,hs-CRP、IL-1β、TNF-α水平显著高于对照组(P<0.05);突发性耳聋患者SIRT1水平与hs-CRP、IL-1β、TNF-α水平分别呈负相关(r=-0.524,-0.384,-0.542,均P<0.05),PGC-1α水平与hs-CRP、IL-1β、TNF-α水平分别呈负相关(r=-0.429,-0.457,-0.624,均P<0.05);预后不良组hs-CRP、IL-1β、TNF-α水平显著高于预后良好组,SIRT1、PGC-1α水平显著低于预后良好组,有高血压史、糖尿病史比例高于预后良好组(P<0.05);Logistic回归分析显示,SIRT1、PGC-1α、hs-CRP、IL-1β、TNF-α、高血压史、糖尿病史是突发性耳聋患者听力预后的影响因素(P<0.05)。结论 SIRT1、PGC-1α在突发性耳聋患者血清中呈低表达,二者与血清炎性因子密切相关,且是听力预后的影响因素。

    Abstract:

    Objective To investigate the correlation between serum silence information regulator homolog 1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and serum inflammatory factors and hearing prognosis in patients with sudden deafness. Methods A total of 88 patients with sudden deafness accepted by mudanjiang second people"s hospital from May 2020 to May 2022 were taken as the study group, the patients were grouped into good prognosis group and poor prognosis group according to their hearing recovery, in addition, 82 healthy people who had physical examination in mudanjiang second people"s hospital were collected as the control group. The levels of serum SIRT1, PGC-1α, inflammatory factor-tumor necrosis factor-α (TNF-α), interleukin-1β (L-1β) and hypersensitive C-reactive protein (hs-CRP) were measured by enzyme-linked immunosorbent assay. Pearson method was applied to analyze the correlation between the levels of serum SIRT1, PGC-1α and inflammatory factors. Logistic regression analysis was applied to analyze the influencing factors of hearing prognosis. Results The proportions of hypertension and diabetes in the study group were higher than those in the control group, and the levels of SIRT1 and PGC-1α were obviously lower than those in the control group, the levels of hs-CRP, IL-1β and TNF-α in the control group were obviously higher than those in the control group (P<0.05); the level of SIRT1 was negatively correlated with the levels of hs-CRP, IL-1β and TNF-α in patients with sudden deafness (r=-0.524, -0.384, -0.542, all P<0.05), the level of PGC-1α was negatively correlated with the levels of hs-CRP, IL-1β and TNF-α (r=-0.429, -0.457, -0.624, all P<0.05); the levels of hs-CRP, IL-1β and TNF-α in the poor prognosis group were obviously higher than those in the good prognosis group, the levels of SIRT1 and PGC-1α were obviously lower than those in the good prognosis group, and the proportions of patients with hypertension and diabetes were higher than those in the good prognosis group (P<0.05); Logistic regression analysis showed that SIRT1, PGC-1α, hs-CRP, IL-1β, TNF-α, history of hypertension, and history of diabetes were the influencing factors of hearing prognosis in patients with sudden deafness (P<0.05). Conclusion SIRT1 and PGC-1α are low expressed in the serum of patients with sudden deafness, and they are closely related to serum inflammatory factors, and are influential factors of hearing prognosis.

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  • 收稿日期:2024-03-27
  • 最后修改日期:2024-05-24
  • 录用日期:2024-05-27
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