Abstract:Neuro-immune (N-I) research focuses on the interaction mechanisms between the nervous systems and the immune systems, including the central cortex and associated nuclei as well as various immune cells. Both peripheral and central interactions between each other exist. Based on findings from different lines of research as well as that from airway inflammation, the concept of "nose-brain axis" was proposed. The keystone of this concept is to decode the mechanisms of how peripheral inflammation affects the central nervous system (CNS), and how the CNS regulates peripheral inflammation. While the role of allergic rhinitis (AR) on CNS has received relatively more attention, its mechanisms remain unclear. On the other hand, less focus was inferred to the CNS regulation on AR, not to mention the exploration into the mechanisms behind it. Understanding the N-I mechanisms of AR and CNS interaction help provide new insights into the pathogenesis of AR and offer novel therapeutic approaches for clinical practice