Methods: The chemical composition of TBXTG was detected by UPHLC-MS. 60 SPF SD rats were used. 10 served as normal controls, while the remaining were randomly divided into model, clarithromycin, and low-, medium-, and high-dose TBXTG groups (10 per group). After modeling establishment, all treatment groups received oral gavage for two weeks. Assessments included HE staining (to evaluate nasal mucosal inflammation), immunofluorescence (M1/M2 polarization), and immunohistochemistry (PACAP, IL-10, TGF-β, ECP). Serum levels of PACAP and cytokines (IL-10, TGF-β, TNF-α, IL-6) were determined by ELISA. Data were analyzed using GraphPad Prism 9.5.0 and Image-Pro Plus 6.0.